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PrEP Facts: What are the ways to take PrEP?

How you take PrEP depends on the dosing options available to you.

How you take PrEP depends on the dosing options available to you. Both Truvada PrEP and Descovy PrEP can be taken with or without food and with alcohol. PrEP also has relatively few drug interactions with other medicines or supplements.

What is Daily PrEP?

With daily PrEP, the drugs are at protective levels in your body at all times. Anyone can choose daily PrEP, but it may be especially helpful if you’re having sex frequently (two or more times per week), if you’re not sure when you’ll have sex next, or if you’re sharing needles.

When taking daily PrEP, it’s wise to pair it with a daily routine or habit—for example, when you first wake up, brush your teeth, or take your hormones. Some people use a daily alarm or other device like a pill bottle timer cap to remind them.

Take your doses about the same time each day, although it’s safe to take a dose an hour or two earlier or later. If you have minor side effects, try taking PrEP with food rather than without (or vice versa) or before bed.

What is PrEP 2-1-1?

PrEP 2-1-1 is good for times when you can plan ahead for sex and/or are having sex less frequently. If you’re having sex once a week or less, then PrEP 2-1-1 may be easier to use (and less expensive) than daily PrEP. Only Truvada has been studied as 2-1-1, so do not use this dosing strategy with Descovy until more is known.

PrEP 2-1-1 has only been studied in gay and bisexual men and transgender women. Without good data on PrEP 2-1-1 for vaginal or front hole sex or blood exposures, PrEP 2-1-1 is not currently recommended for people who have vaginal or front hole sex, or for people who share needles.

Taking PrEP 2-1-1 means being more attentive to timing the doses of Truvada. Following the numbers (2-1-1), take two pills together 24 to 2 hours before anticipated sex, take one pill 24 hours after the first two, and then take one more pill 24 hours after that. Take your doses as close to the same time each day as possible. 

If you have sex more than once over more than one day, take two daily doses after the last time you had sex. For a graphic that illustrates 2-1-1, click here for English and click here for Spanish

Switching between daily and 2-1-1

The sex you have may change over time as your circumstances change, such as during a new relationship or a break-up, or periods of heavy stress or work. If you are eligible to use PrEP 2-1-1—that is, if you only have anal sex and are a cisgender man or a trans woman—you can switch between daily and PrEP 2-1-1 (and vice versa) as your needs change.

PrEP 2-1-1 for Anal Sex: An Example

Meet Sam

It’s Saturday, and Sam is pretty sure he’s going to hook up with someone at a party later that night…

PrEP 2-1-1 for Anal Sex: An Example

First dose: 2 pills

To start PrEP 2-1-1, Sam takes two pills between 2 and 24 hours before sex.

The party starts at 10 pm so Sam takes his first two pills at 8 pm—two hours before any action might happen.

At the party, Sam has sex with Stevie at 11 pm and with Tony at 2 am. He has sex again on Sunday with Tony at 7 pm.

PrEP 2-1-1 for Anal Sex: An Example

Next dose: 1 pill

Sam knows that he needs to continue taking one pill every 24 hours, for as long he plans to have sexual encounters.

Sam takes his next single pill on Sunday at 8 pm (24 hours after his first dose on Saturday) and doesn’t have, or plan to have, more sex.

PrEP 2-1-1 for Anal Sex: An Example

Last dose: 1 pill

Now that Sam has stopped having sexual encounters for at least 24 hours, he only needs to take one more pill.

Sam takes another single pill on Monday at 8pm (24 hours after his dose on Sunday). It’s been at least 24 hours since he’s had sex so this is his final dose.

PrEP Facts content written by Alan McCord and Reilly O’Neal. Medical review by Janessa Broussard, RN, MSN, AGNP-C, vice president of medical affairs at San Francisco AIDS Foundation.