Doxy PEP: Prevents STIs

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Suck off your regular sweetie, or get after that hot anonymous cock — without fear. Doxy PEP is here to make sure you can suck, fuck, get pounded raw AND prevent STIs.

Who is it for?

Doxy PEP is for gay, bi, or hetero cis guys, plus trans, non-binary, and TGNCI+ folx* who want to protect themselves from gonorrhea, chlamydia, and syphilis.

At this time, it’s under study with cis women. We will let you know when we know more about how well this works for cis women.

How does it work?

By taking two pills (100 mg each) of the antibiotic doxycycline (“Doxy”) within 24 to 72 hours of fucking or sucking as the top, bottom, or both, you can stop the spread of STIs. One dose of Doxy PEP will cover all the sex you’ll have in a day — so make Doxy PEP your last load of the night. Don’t take more than two pills (one dose) in a 24 hour period.

What is the cost?

It’s a generic medication that costs less than $20/bottle. Check GoodRx for coupons that can lower the cost of your prescription.

How do I get it?

If your doctor, nurse, and/or healthcare provider doesn’t know about Doxy PEP, show them this letter.

More questions?

We’ve got loads more info here.

What don't we know? 

Doxy PEP is a relatively new prevention strategy. Drug resistance with Doxy PEP is currently being studied further, and is certainly a consideration for the public and health organizations as use of this strategy increases. Doxy PEP is an individual decision and folks will need to weigh the benefits (STI prevention) with possible risks (including medication side effects) as with any medical decision.

*Doxy PEP is recommended to cis men and trans women who have sex with men with a history of an STI and more than 1 sex partner in the past year by the San Francisco Department of Public Health, due to the fact that studies evaluating Doxy PEP effectiveness have been conducted with people of these identities. SFDPH also recommends shared decision-making around Doxy PEP for trans men, trans women, men who have sex with men with multiple partners. San Francisco AIDS Foundation further recommends Doxy PEP to trans men, trans women, and cis men who report having multiple cis men or trans women sex partners in the previous year. Studies with cis women are ongoing.

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