Sexual health

Mpox FAQ

What is mpox, and do I need to be worried about it? SFAF clinicians share their perspective.

Preguntas Frecuentes sobre la viruela del mono [Spanish]

A curiously-named viral infection–mpox–is in the news right now causing concern among public health officials and the general public. The infection is caused by a virus similar to the one that causes smallpox.

Although rare outside of Central and West Africa, cases of mpox have been reported recently among a handful of gay and bisexual men in Europe, and a few cases have also been reported in the U.S. 

Here, San Francisco AIDS Foundation clinicians Hyman Scott, MD, MPH, medical director, and Jorge Roman, MSN, FNP-BC, AAHIVS, director of clinical services, answer our questions about mpox.

What are the symptoms?

People may get flu-like symptoms, including fever, headache, and fatigue. 1-3 days later, people may get a rash on the face, arms, legs (including the palms of the hands and soles of the feet), and genitals. It usually takes around 6 – 13 for symptoms to appear (the “incubation period”). Over the course of the infection, the rash will change: first, it will appear as flat lesions, will progress to raised and firm lesions, then will fill with fluid, and finally will develop crusts which will dry and fall off. 

With recent mpox cases, people have developed the rash around their genitals and/or anus (butt) first. Many of these cases were detected at STI clinics, with symptoms that appear like common STIs including syphilis or genital herpes. 

How long are people infectious?

People are infectious when symptoms begin until lesions have healed. This may take 2-4 weeks. 

How is mpox transmitted? 

Mpox can be passed from person to person in a few different ways, although this was thought to be rare in previous outbreaks. The virus can also be transmitted through respiratory droplets, which means that you can get it by kissing, sharing drinks, or breathing the same air as someone who has the virus. You can get mpox through body fluids (it’s not currently known if it can be transmitted through semen or vaginal fluid) and touching the lesions and rash created by the virus can also transmit the virus, as can coming into contact with viral particles that may be present on clothing or bedding used by someone with mpox. 

The World Health Organization reports that, “the main way it can spread is through close physical contact, including sexual contact, with someone who has [mpox].” 

Are gay and bisexual men at higher risk?

This infection has occurred among some men who have sex with men in Europe, so public health officials have shared this association which was identified during case investigations. Mpox can affect anyone, however, and there’s no specific biological reason for men who have sex with men to be at any higher risk. 

Like any transmittable infection, a higher “risk” might simply come from being part of social or sexual networks that include other people who have the infection. For cases that occurred in Europe, the World Health Organization has linked transmissions to two Queer events–one in Spain and the other in Belgium.   

How do I get tested for mpox?

If you have a rash on your genital and/or anal area, and/or on face, hands/feet, and other areas of the body, healthcare providers can test the rash to see if it might be caused by mpox or a different infection.

How is it treated? 

There isn’t any specific treatment for mpox infection, but healthcare professionals can treat the infection with treatments for smallpox and other antiviral medications. 

Is the infection serious?

Many people recover from mpox without treatment in a few weeks. The infection can cause severe disease and even death, so treatment is recommended–especially for people who may be at higher risk including people who are immunocompromised, children, and pregnant people. With the strain of mpox that is currently circulating, risk of mortality is low (less than 1%). 

What should I do if I develop a rash?

There are many different causes of rashes, and at this point, mpox is extremely rare. Contact your primary care provider if you have symptoms or an unexplained rash, or come see us at Magnet to get tested for mpox. SFAF’s clinic, Magnet, is available for diagnosis and treatment for people that develop rashes around their genitals or anus that may be caused by mpox or another infection. 

What else should we know?

With festival season, Pride, and summer events approaching, it’s a great idea to check in on your sexual health! We recommend regular sexual health care visits and STI testing for people who are sexually active. Although mpox is rare, many STIs including gonorrhea, chlamydia, and syphilis are much more common.

About the author

San Francisco AIDS Foundation

San Francisco AIDS Foundation promotes health, wellness and social justice for communities most impacted by HIV through sexual health and substance use services, advocacy, and community partnerships. Each year more than 21,000 people rely on SFAF programs and services, and millions more access SFAF health information online.